Friday, August 12, 2011

Difference in hippocampus?

I'm trying to get atleast a tangential grasp on the hippocampus. Ca fields, dendritic arborization, LTP, neurogenesis, hilar ectopic cells, basal cholinergic forebrain, role of microglia, svz, sgz, beta3 adrenergic receptors, GFAP fx, dhea/cortisol/hpa-axis--/dht,androstenon… (vomeronasal organ{svz} ), 17 beta-E2, Er-alpha, dht, vegf, bdnf/respiration induced positive feedback loop--anti-senscence (probably sirtuins involved) ,Anti-depressants etc.. / left-brain hyper-axonal length/awareness/low corpus callosum connectivity to right/ occipital--temporo-parietal junction--dorsolateral pfc. Basically, I'm trying to figure out the differences between rats & mice in comparison to humans but I have not yet found a site which details the genetic sequence of rats and mice compared with humans. It seems that there are dissimilarities and similarities alike in different regions. Would like an informed perspective on the role and/or importance of these and what kind of treatment could you theoretically give to someone like representative Giffords? It would seem that there are a number of neurotrophic factors which include prolactin even, strange as it sounds. I guess I'm asking for someone to opine based not on the exact extent of the injury (since this can change in some ways by rebranching/re-routing) but, on positive feedback loop induced cascades and possible M.O.A's of pharmacokinetics/therapy involved.

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